Description :
Hepatitis B Immunoglobulin (HBIG) is a sterile solution of human antibodies that provides immediate, short-term protection against hepatitis B infection. It is used for post-exposure prophylaxis in individuals who have been exposed to the hepatitis B virus (HBV), such as through needle-stick injuries, sexual exposure, or contact with contaminated blood. It is also given to newborns of hepatitis B-positive mothers alongside the hepatitis B vaccine to prevent transmission.
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Dosage
Adults (Post-exposure): 0.06 mL/kg intramuscular (IM) injection, as soon as possible (preferably within 24 hours, up to 7 days).
Newborns (from infected mothers): 0.5 mL IM within 12 hours of birth, along with the first dose of the hepatitis B vaccine.
Other exposures (needle-stick, mucosal contact): 0.06 mL/kg IM once, plus hepatitis B vaccination if not previously immunized.
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Side Effects
Common:
Injection site pain, redness, or swelling
Headache, mild fever, fatigue
Nausea
Serious (rare):
Allergic reactions (rash, itching, swelling, breathing difficulty)
Low blood pressure (anaphylaxis – very rare
Warnings & Precautions
Must be given within 24 hours of exposure for maximum effectiveness.
Does not replace the need for the hepatitis B vaccine series.
Use with caution in individuals with IgA deficiency or history of severe allergic reactions.
Store in a refrigerator (2–8°C), do not freeze.
Only given by trained healthcare professionals.
