Oncology / Hormonal Therapy / Prostate Cancer Treatment
Casodex 50mg
Description :
Casodex contains bicalutamide, a non-steroidal anti-androgen (androgen receptor inhibitor). It blocks testosterone from binding to prostate cancer cells, slowing their growth. Casodex is used in combination with an LHRH analog (such as goserelin or leuprolide) to treat metastatic (Stage D2) prostate cancer, helping control disease progression.
Dosage (Adults—Male only)
Standard dose: 50 mg once daily, with or without food, taken at the same time each day.
Always administered with an LHRH analog—start both treatments concurrently.
Higher doses (e.g., 150 mg) have been studied but are not approved due to increased risks.
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Side Effects
Common:
Hot flashes (flushing, sweating)†
Weakness, body aches, joint/back/pelvic pain
Gastrointestinal disturbances: nausea, constipation, diarrhea
Peripheral edema (swelling of ankles, legs, arms)
Urinary symptoms, nighttime urination, anemia
Serious:
Liver toxicity (jaundice, dark urine, stomach pain)
Breast enlargement and/or pain (gynecomastia)
Rare allergic reactions; bleeding, vision changes, mood alterations
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Warnings & Precautions
Not for use in women or children—it may cause serious harm.
Monitor PSA levels routinely to assess treatment response.
Regularly check liver function tests, especially early in treatment.
May raise blood sugar levels—caution in diabetic patients.
Handle with care—women who are pregnant or may become pregnant should not touch broken tablets.
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Effectiveness
Combining Casodex with an LHRH analog is more effective than LHRH analog alone and comparable to flutamide combination in prolonging survival and delaying progression.
