Caspofungin acetate is an echinocandin antifungal medicine used for serious fungal infections. It works by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of fungal cell walls—leading to the death of susceptible fungi.
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Indications / Uses
Invasive candidiasis (including candidemia)
Esophageal candidiasis
Empirical therapy for presumed fungal infections in febrile, neutropenic patients
Invasive aspergillosis (in patients intolerant of or refractory to other treatments)
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Dosage & Administration (as directed by a healthcare professional)
Typical adult dose: Loading dose 70 mg IV on Day 1, then 50 mg IV once daily.
Pediatric dose: As prescribed by the physician based on body surface area.
Administer intravenously over ~1 hour after reconstitution and dilution.
Not for bolus injection.
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Precautions & Warnings
Contraindication: Known hypersensitivity to caspofungin or any component of the formulation.
Caution: Liver impairment may require dose adjustment.
Monitor liver enzymes during therapy.
Pregnancy & lactation: Use only if clearly needed and prescribed.
Not a substitute for antibacterial treatment in mixed infections.
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Possible Side Effects
Mild: Fever, headache, nausea, flushing, injection site reactions.
Serious (seek medical attention): Rash, breathing difficulties, signs of liver dysfunction (yellowing of eyes/skin).
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Drug Interactions
Cyclosporine may increase liver enzyme elevations.
Rifampin and some enzyme inducers can lower caspofungin levels—dose adjustment may be needed.
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Storage
Store vials refrigerated at 2°C–8°C (36°F–46°F).
Protect from light.
Use reconstituted solution promptly or follow manufacturer’s guidance.
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Packaging
Single-use glass vial containing sterile lyophilized powder.
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Disclaimer
This product is to be used only with a valid prescription and under the supervision of a qualified healthcare professional. Information provided here is for educational purposes and not a substitute for professional medical advice.
