Oncology / Hormonal Therapy / Prostate Cancer Treatment
Leuprolide Acetate Injection
Description :
Leuprolide Acetate Injection is a gonadotropin-releasing hormone (GnRH) agonist used to suppress hormone production in the body. It is commonly prescribed in the treatment of advanced prostate cancer, endometriosis, uterine fibroids, and central precocious puberty (early puberty in children). By reducing estrogen and testosterone levels, it slows disease progression and helps control symptoms.
Dosage
Prostate Cancer (Adults):
7.5 mg intramuscular (IM) injection once monthly OR depot formulations of 22.5 mg every 3 months, 30 mg every 4 months, or 45 mg every 6 months.
Endometriosis / Uterine Fibroids (Women):
3.75 mg IM injection every month OR 11.25 mg every 3 months (usually limited to 6 months of therapy).
Central Precocious Puberty (Children):
Dose depends on body weight, typically 7.5–15 mg IM every month.
👉 Dose and frequency depend on the condition and depot strength prescribed by the doctor.
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Side Effects
Common:
Hot flashes, sweating
Headache, dizziness
Injection site pain/redness
Mood changes, fatigue
Decreased libido
Serious (rare):
Osteoporosis (long-term use)
Cardiovascular issues (palpitations, chest pain)
Severe allergic reaction (rash, swelling, breathing problems)
High blood sugar in diabetic patients
Warnings & Precautions
May initially cause “tumor flare” (temporary worsening of symptoms) before hormone suppression begins.
Long-term use may cause bone thinning (osteoporosis) – calcium/vitamin D supplements may be advised.
Use with caution in patients with heart disease, diabetes, or depression.
Not to be used during pregnancy or breastfeeding.
Regular monitoring of hormone levels and bone density may be required.
